The Insect Antimicrobial Peptide Database (IAMPDB) represents a specialized database of insect-derived antimicrobial peptides (IAMPs). The data are sourced from UniProt and its associated literature from PubMed. Currently, the database holds 438 entries of IAMPs from 148 insects across 10 taxonomical insect orders. The data can be used to target 181 microorganisms and study 33 activities. Researchers, scientists, and pharmaceutical industries can utilize this database for drug development, disease-resistant crop development, and more.
ABSTRACT
Insects, a majority of animal species, rely on innate immunity and antimicrobial peptides (AMPs), which are a part of their innate immunity, to combat diverse parasites and pathogens. These peptides have applications ranging from agriculture to antimicrobial resistance (AMR). However, there is a lack of a specialized database, prompting the development of the Insect Antimicrobial Peptide Database (IAMPDB) as a pioneering comprehensive Knowledgebase dedicated to
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nsect-derived antimicrobial peptides (IAMPs), serving as a resource for researchers and industry professionals. Curated from UniProt and associated literature(s), IAMPDB currently houses 438 curated entries of IAMPs from various insect species, spanning 10 taxonomical orders of insects. Each entry is meticulously annotated with details on peptide sequence, source organism, activities, physicochemical properties, and more. IAMPDB offers a user-friendly interface with diverse search options, interactive visualizations, and links to external databases; advanced tools, including a peptide sequence alignment toolbox and a peptide feature calculation toolbox, facilitating sequence alignment, physicochemical property calculation, and in-depth analysis. The knowledgebase is accessible online (at URL https://bblserver.org.in/iampdb/).
