22nd GFPP meeting

Sunday, May 29

Sylviane Muller (Strasbourg University, France )
“Mechanism-guided novel therapies for treating inflammatory diseases”

Monday, May 30

SESSION 1

“Gut-stable peptide therapeutics“

“Design, synthesis and characterization of monoclonal antibody mimics”

“Downsizing Nanobodies: towards CDR3 loop peptidomimetics enhancing SOS1-mediated nucleotide exchange on RAS” 

“Cyclic Peptides Targeting VEGF/VEGFR Interaction for Anti-angiogenic Therapy”

SESSION 2

“From the lead peptide BP100 to bifunctional peptide conjugates to control plant pathogens”

“Untying the Gordian Knot: unravelling spatiotemporal activity in the C. elegans neuropeptide-receptor network”

“Investigation of the U₉-MYRTX-Tb1a mechanism, a cytotoxic peptide from the ant Tetramorium bicarinatum venom“

SESSION 3

“Transition Metals in Peptide and Protein Synthesis”

“5-Hydroxy-pyrrol-2-one based building blocks as maleimide alternatives for protein bioconjugation”

“Sequence-specific recognition of double-stranded DNA: Application to luminescence sensing”

BIOTECH SESSION

”The cell-free technology for the futures of protein… and even more !”

“Challenges for the Delivery of Peptides and  Proteins: Opportunities for Innovative Long-Acting    Injectable Technologies”

“Peptiligase enzymes as enabling technology for long and complex peptides”

“Oncomimics™ : New peptide-based immunotherapies from bench to bedside“

“The Confo Therapeutics Technology Platform Enabling GPCR Fragment-based Drug Discovery“           

With the participation of GenePep and Corden Pharma

Tuesday, May 31

SESSION 4

“Fluorescent activatable peptides for first in-human imaging studies”

“Synthesis and in vivo characterization of a heterobivalent radiotracer targeting PSMA and GRPR for prostate cancer imaging”

“Bimodal Nb-tracers for rapid and specific pre-and intra-operative cancer imaging”

“P-functionalized fluorescent phospholes for chemioselective coupling to peptides under mild conditions”

SESSION 5

“Activity-based probes targeting metalloproteinases with no photoactivation: toward the profiling of these enzymes in vivo?”

“Development of MS molecular probes – ABP – for the profiling of matrix metalloproteases using MALDI-MS “

“Recombinant Production, Labeling, Purification and Interaction of Death Receptor 5 with Multivalent Peptides”

SESSION 6

 “Allosteric modulation of GPCR signaling”

“Furan-oxidation mediated cross-link technology: from in vitro analysis of protein-protein interactions to covalent GPCR-ligand interactions on live cells”

“Development of G protein peptidomimetics able to stabilize active state G_s protein-coupled receptors for application in drug discovery”

SESSION 7

“Miniaturized peptide toxins in drug discovery: pro & con’s”

“Characterization of innovative animal toxins for the functional study of angiotensin receptors”

Wednesday, June 1

SESSION 8

“Protein semisynthesis to dissect cellular regulation by posttranslational modifications”

“N-[2-thioethyl]glycine as a new thioesterification tool for peptide synthesis by native chemical ligation”

“Aspartimide formation, an underestimated side reaction during NCL. Development of a straightforward methodology to overcome it”

“Role of matrix Gla protein in vascular calcification: hard chemistry for soft vessels”

SESSION 9

“Hybrid multi-tasking peptides and their ionic liquid conjugates as promising leads to tackle severe skin and soft tissue infections”

“Peptide-based siRNA delivery: Licence to silence”

“Development of Hepatitis C viral fusion peptides and constrained analogues for cell-penetration”

 Thursday, June 2

SESSION 10

“Polypeptides from novel approaches in polymer chemistry”

“Impact of peptide length on in vivo hydrogel stability and sustained drug release”

“Novel hybrid precursors for sol-gel protein imprinting: silylated amino acid derivatives”

“Hybrid apatite/peptide colloidal nanoparticles for the treatment of complex wounds” 

SESSION 11

“Heterocyclic g-peptide foldamers: from conformational control to applications in organocatalysis and biomedical areas”

“Fluorinated Peptide Approach for the Inhibition of Rotamase”

“Towards stochastic control of peptidic copolymer sequences”

“Optimization of urea-based foldamers as ligands to target the histone chaperone ASF1 (Anti-Silencing Function 1)”

SESSION 12

 “Foldamers as Protein Mimics”

“Peptidomimetic foldamers: a new feature for the amyloidogenic pathology of Alzheimer’s disease”

“Dynamic hybridization of quinoline oligoamides into heteromeric double helices: towards stabilization of protein complexes”

“DE NOVO design of peptides self-assembling into left-handed β helices”

SESSION 13

“Structural investigations of bacterial lipopeptides: challenges and (some) solutions”

“An NMR Fingerprint matching methodology for identification and structural evaluation of non-ribosomal lipopeptides”

Friday, June 3

SESSION 14

“Mimicking biocatalysis for the design of artificial oxygenases based on a versatile protein scaffold”

“De novo designed coiled-coil peptides that assemble and function in living cells”

“Copper binding peptides for sustainable oxidation reactions”