An expanding body of evidence shows that synthetic peptides in combination with radioactive isotopes can be utilized for medical purposes. This review summarizes the contributions in this area made by the group originally founded by Carlo Pedone in Naples many years ago. The work of this group is highlighted in the context of other developments in this area.
There is an expanding body of evidence showing that synthetic peptides in combination with radioactive isotopes can be utilized for medical purposes. This area is of particular interest in oncology where applications in diagnosis and therapy are at different stages of development. We review the contributions in this area by the group originally founded by Carlo Pedone in Naples many years ago. We highlight the work of this group in the context of other developments in this area, focusing on three biologically relevant receptor systems: somatostatin, gastrin-releasing peptide, and cholecystokinin-2/gastrin receptors. We focus on key milestones, state of the art, and challenges in this area of research as well as the current and future outlook for expanding clinical applications.
